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Table one summarizes the observed DLTs by cohort. Somnolence, which settled in all but a person patient, was the only real DLT for MLN8054 given with no methylphenidate or modafinil. The onset of somnolence and its severity typically were correlated with dose and Cmax. Because somnolence was thought to be relevant to Cmax, the dosing program was al

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